Structure of PDB 8ppe Chain A

Receptor sequence
>8ppeA (length=272) Species: 9606 (Homo sapiens) [Search protein sequence]
GSHMSWVSFKAAGTSGLILKRCSEPERYCLARLMADALRGCVPAFHGVVE
RDGESYLQLQDLLDGFDGPCVLDCKMGVRTYLEEELTKARERPKLRKDMY
KKMLAVDPEAPTEEEHAQRAVTKPRYMQWREGISSSTTLGFRIEGIKKAD
GSCSTDFKTTRSREQVLRVFEEFVQGDEEVLRRYLNRLQQIRDTLEVSEF
FRRHEVIGSSLLFVHDHCHRAGVWLIDFGKTTPLPDGQILDHRRPWEEGN
REDGYLLGLDNLIGILASLAER
3D structure
PDB8ppe Substrate promiscuity of inositol 1,4,5-trisphosphate kinase driven by structurally-modified ligands and active site plasticity
ChainA
Resolution1.59 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.127: inositol-trisphosphate 3-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A H185 F198 K209 Q249 D250 L251 I415 D416 H3 F9 K20 Q60 D61 L62 I226 D227
BS02 7I8 A R285 K312 Y315 R319 K419 R96 K123 Y126 R130 K230
Gene Ontology
Molecular Function
GO:0016301 kinase activity
Biological Process
GO:0032958 inositol phosphate biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8ppe, PDBe:8ppe, PDBj:8ppe
PDBsum8ppe
PubMed38374076
UniProtP23677|IP3KA_HUMAN Inositol-trisphosphate 3-kinase A (Gene Name=ITPKA)

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