Structure of PDB 8ppc Chain A

Receptor sequence
>8ppcA (length=276) Species: 9606 (Homo sapiens) [Search protein sequence]
GSHMSWVQLAGSFKAAGTSGLILKRCSEPERYCLARLMADALRGCVPAFH
GVVERDGESYLQLQDLLDGFDGPCVLDCKMGVRTYLEEELTKARERPKLR
KDMYKKMLAVDPEAPTEEEHAQRAVTKPRYMQWREGISSSTTLGFRIEGI
KKADGSCSTDFKTTRSREQVLRVFEEFVQGDEEVLRRYLNRLQQIRDTLE
VSEFFRRHEVIGSSLLFVHDHCHRAGVWLIDFGKTTPLPDGQILDHRRPW
EEGNREDGYLLGLDNLIGILASLAER
3D structure
PDB8ppc Substrate promiscuity of inositol 1,4,5-trisphosphate kinase driven by structurally-modified ligands and active site plasticity
ChainA
Resolution1.92 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.1.127: inositol-trisphosphate 3-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2KM A R285 M288 K312 Y315 M316 R319 K419 R100 M103 K127 Y130 M131 R134 K234
BS02 ATP A H185 F198 K209 Q249 D250 L251 K336 D416 H3 F13 K24 Q64 D65 L66 K151 D231
Gene Ontology
Molecular Function
GO:0016301 kinase activity
Biological Process
GO:0032958 inositol phosphate biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8ppc, PDBe:8ppc, PDBj:8ppc
PDBsum8ppc
PubMed38374076
UniProtP23677|IP3KA_HUMAN Inositol-trisphosphate 3-kinase A (Gene Name=ITPKA)

[Back to BioLiP]