Structure of PDB 8ppb Chain A

Receptor sequence
>8ppbA (length=276) Species: 9606 (Homo sapiens) [Search protein sequence]
GSHMSWVQLAGSFKAAGTSGLILKRCSEPERYCLARLMADALRGCVPAFH
GVVERDGESYLQLQDLLDGFDGPCVLDCKMGVRTYLEEELTKARERPKLR
KDMYKKMLAVDPEAPTEEEHAQRAVTKPRYMQWREGISSSTTLGFRIEGI
KKADGSCSTDFKTTRSREQVLRVFEEFVQGDEEVLRRYLNRLQQIRDTLE
VSEFFRRHEVIGSSLLFVHDHCHRAGVWLIDFGKTTPLPDGQILDHRRPW
EEGNREDGYLLGLDNLIGILASLAER
3D structure
PDB8ppb Substrate promiscuity of inositol 1,4,5-trisphosphate kinase driven by structurally-modified ligands and active site plasticity
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.127: inositol-trisphosphate 3-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3I2 A R285 M288 K291 K312 Y315 R319 K419 R100 M103 K106 K127 Y130 R134 K234
BS02 ATP A H185 F198 K209 Q249 D250 L251 D262 K336 I415 D416 H3 F13 K24 Q64 D65 L66 D77 K151 I230 D231
Gene Ontology
Molecular Function
GO:0016301 kinase activity
Biological Process
GO:0032958 inositol phosphate biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8ppb, PDBe:8ppb, PDBj:8ppb
PDBsum8ppb
PubMed38374076
UniProtP23677|IP3KA_HUMAN Inositol-trisphosphate 3-kinase A (Gene Name=ITPKA)

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