Structure of PDB 8pp0 Chain A

Receptor sequence
>8pp0A (length=214) Species: 9606 (Homo sapiens) [Search protein sequence]
EDMPVERILEAELAVEPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPL
DDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGA
IFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALRE
KVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGD
TPIDTFLMEMLEAP
3D structure
PDB8pp0 Structure-Guided Design of a Highly Potent Partial RXR Agonist with Superior Physicochemical Properties.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A F277 V280 K284 Q297 V298 R302 E453 F33 V36 K40 Q53 V54 R58 E209
BS02 7QJ A I268 A272 Q275 W305 N306 I310 F313 R316 L326 A327 I24 A28 Q31 W61 N62 I66 F69 R72 L82 A83
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003707 nuclear steroid receptor activity
GO:0008270 zinc ion binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8pp0, PDBe:8pp0, PDBj:8pp0
PDBsum8pp0
PubMed38237049
UniProtP19793|RXRA_HUMAN Retinoic acid receptor RXR-alpha (Gene Name=RXRA)

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