Structure of PDB 8pon Chain A

Receptor sequence
>8ponA (length=200) Species: 9606 (Homo sapiens) [Search protein sequence]
GLGTARLQLVEFSAFVEPPQRHLFVHISQHPPLESVDVRQIYDKFPEKKG
GLRELYDRGPPHAFFLVKFWADLNWSSGGFYGVSSQYESLEHMTLTCSSK
VCSFGKQVVEKVETERAQLEDGRFVYRLLRSPMCEYLVNFLHKLRQLPER
YMMNSVLENFTILQVVTNRDTQELLLCTAYVFEVSTSERGAQHHIYRLVR
3D structure
PDB8pon Development of LM-41 and AF-2112, two flufenamic acid-derived TEAD inhibitors obtained through the replacement of the trifluoromethyl group by aryl rings.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZUT A F233 V329 S345 K346 V347 K357 M379 C380 L383 I408 F12 V83 S99 K100 V101 K111 M133 C134 L137 I162
External links
PDB RCSB:8pon, PDBe:8pon, PDBj:8pon
PDBsum8pon
PubMed37770003
UniProtQ15562|TEAD2_HUMAN Transcriptional enhancer factor TEF-4 (Gene Name=TEAD2)

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