Structure of PDB 8pok Chain A

Receptor sequence
>8pokA (length=278) Species: 9606 (Homo sapiens) [Search protein sequence]
DSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAI
TDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMI
SLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRN
ESKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHIS
SWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLE
AIVLWLGYANSALNPILYAALNRDFRTG
3D structure
PDB8pok Cryo-EM structure of cell-free synthesized human histamine 2 receptor/G s complex in nanodisc environment.
ChainA
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HSM A D104 Y256 D86 Y230
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004969 histamine receptor activity
GO:0004993 G protein-coupled serotonin receptor activity
GO:0030594 neurotransmitter receptor activity
Biological Process
GO:0001696 gastric acid secretion
GO:0006955 immune response
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007268 chemical synaptic transmission
GO:0045907 positive regulation of vasoconstriction
GO:0098664 G protein-coupled serotonin receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030425 dendrite
GO:0045202 synapse

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Cellular Component
External links
PDB RCSB:8pok, PDBe:8pok, PDBj:8pok
PDBsum8pok
PubMed38418462
UniProtP25021|HRH2_HUMAN Histamine H2 receptor (Gene Name=HRH2)

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