Structure of PDB 8poj Chain A

Receptor sequence
>8pojA (length=189) Species: 9606 (Homo sapiens) [Search protein sequence]
GLGTARLQLVEFSAFVEPRHLFVHISQPLESVDVRQIYDKFPELRELYDR
GPPHAFFLVKFWADLNWGFYGVSSQYESLEHMTLTCSSKVCSFGKQVVEK
VETERAQLEDGRFVYRLLRSPMCEYLVNFLHKLRQLPERYMMNSVLENFT
ILQVVTNRDTQELLLCTAYVFEVSTSERGAQHHIYRLVR
3D structure
PDB8poj Development of LM-41 and AF-2112, two flufenamic acid-derived TEAD inhibitors obtained through the replacement of the trifluoromethyl group by aryl rings.
ChainA
Resolution2.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZUL A F233 V329 S345 K346 V347 V355 K357 M379 C380 I408 F428 F12 V72 S88 K89 V90 V98 K100 M122 C123 I151 F171
External links
PDB RCSB:8poj, PDBe:8poj, PDBj:8poj
PDBsum8poj
PubMed37770003
UniProtQ15562|TEAD2_HUMAN Transcriptional enhancer factor TEF-4 (Gene Name=TEAD2)

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