Structure of PDB 8pod Chain A

Receptor sequence

>8podA (length=321) Species: 9606 (Homo sapiens) [Search protein sequence]

MTTNVGDSTLADLLDHGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGS
WQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHST
QLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQ
GKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVG
TKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDY
KPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKEC
WYQNPSARLTALRIKKTLTKI

3D structure

PDB

8pod Crystal structure of the kinase domain of ACVR1 (ALK2) in complex with FKBP12 and MU1700

Chain

Resolution

2.59 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	7IO	A	V214 V222 A233 K235 L263 T283 H284 Y285 G289 L343 A353	V38 V46 A57 K59 L87 T106 H107 Y108 G112 L166 A176

External links

PDB	RCSB:8pod, PDBe:8pod, PDBj:8pod
PDBsum	8pod
PubMed
UniProt	Q04771\|ACVR1_HUMAN Activin receptor type-1 (Gene Name=ACVR1)

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