Structure of PDB 8po3 Chain A

Receptor sequence
>8po3A (length=279) Species: 9606 (Homo sapiens) [Search protein sequence]
ILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKA
NKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREH
KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITD
FGLAKLLVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGI
PASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEF
SKMARDPQRYLVIQGDERSPTDSNFYRAL
3D structure
PDB8po3 Discovery and Optimization of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations.
ChainA
Resolution2.13 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2II A V726 A743 K745 A763 L788 T790 L792 M793 C797 D800 R841 L844 T854 D855 F856 V21 A38 K40 A58 L83 T85 L87 M88 C92 D95 R136 L139 T149 D150 F151
External links
PDB RCSB:8po3, PDBe:8po3, PDBj:8po3
PDBsum8po3
PubMed38770784
UniProtP00533|EGFR_HUMAN Epidermal growth factor receptor (Gene Name=EGFR)

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