Structure of PDB 8po2 Chain A

Receptor sequence
>8po2A (length=271) Species: 9606 (Homo sapiens) [Search protein sequence]
RILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPK
ANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDY
VREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHV
KITDFGLAKLLGVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSK
PYDGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRE
LIIEFSKMARDPQRYLVIQGD
3D structure
PDB8po2 Discovery and Optimization of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations.
ChainA
Resolution2.28 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R779 K826 K849 H853 K855 I969 R976 R75 K122 K145 H149 K151 I253 R260
BS02 26X A A743 K745 L791 T793 M796 C800 R844 L847 T857 D858 F859 L861 A39 K41 L87 T89 M92 C96 R140 L143 T153 D154 F155 L157
External links
PDB RCSB:8po2, PDBe:8po2, PDBj:8po2
PDBsum8po2
PubMed38770784
UniProtP00533|EGFR_HUMAN Epidermal growth factor receptor (Gene Name=EGFR)

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