Structure of PDB 8po0 Chain A

Receptor sequence
>8po0A (length=310) Species: 9606 (Homo sapiens) [Search protein sequence]
SGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAI
KEKANKEILDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCL
LDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTP
QHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVW
SYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMV
KCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPLMDEEDMD
DVVDADEYLI
3D structure
PDB8po0 Discovery and Optimization of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations.
ChainA
Resolution2.523 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2I6 A L718 A743 E762 M766 L791 T793 M796 P797 C800 R844 L847 L24 A49 E61 M65 L90 T92 M95 P96 C99 R143 L146
External links
PDB RCSB:8po0, PDBe:8po0, PDBj:8po0
PDBsum8po0
PubMed38770784
UniProtP00533|EGFR_HUMAN Epidermal growth factor receptor (Gene Name=EGFR)

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