Structure of PDB 8pka Chain A

Receptor sequence
>8pkaA (length=402) Species: 9606 (Homo sapiens) [Search protein sequence]
LRPLYMDVQATTPLDPRVLDAMLPYLINYYGNPHSRTHAYGWESEAAMER
ARQQVASLIGADPREIIFTSGATESNNIAIKGVARFYRSRKKHLITTQTE
HKCVLDSCRSLEAEGFQVTYLPVQKSGIIDLKELEAAIQPDTSLVSVMTV
NNEIGVKQPIAEIGRICSSRKVYFHTDAAQAVGKIPLDVNDMKIDLMSIS
GHKIYGPKGVGAIYIRRRPRVRVEALQSGGGQERGMRSGTVPTPLVVGLG
AACEVAQQEMEYDHKRISKLSERLIQNIMKSLPDVVMNGDPKHHYPGCIN
LSFAYVEGESLLMALKDVALSSGSACTSASLEPSYVLRAIGTDEDLAHSS
IRFGIGRFTTEEEVDYTVEKCIQHVKRLREMSPLWEMVQDGIDLKSIKWT
QH
3D structure
PDB8pka Mechanism and structural dynamics of sulfur transfer during de novo [2Fe-2S] cluster assembly on ISCU2.
ChainA
Resolution2.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.8.1.7: cysteine desulfurase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP A G126 A127 T128 H156 D232 A234 Q235 S255 H257 K258 G71 A72 T73 H101 D177 A179 Q180 S200 H202 K203
Gene Ontology
Molecular Function
GO:0030170 pyridoxal phosphate binding
GO:0031071 cysteine desulfurase activity
Biological Process
GO:0044571 [2Fe-2S] cluster assembly

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Molecular Function
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Biological Process
External links
PDB RCSB:8pka, PDBe:8pka, PDBj:8pka
PDBsum8pka
PubMed38627381
UniProtQ9Y697|NFS1_HUMAN Cysteine desulfurase (Gene Name=NFS1)

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