Structure of PDB 8pi9 Chain A

Receptor sequence
>8pi9A (length=165) Species: 9606 (Homo sapiens) [Search protein sequence]
SPEEAAHQKAVVETLLQEDPWRVAKMVKSYLQQHNIPQREVVDTTGLNQS
HLSQHLNKGTPMKTQKRAALYTWYVRKQREVAQQFTHARRNRFKWGPASQ
QILFQAYERQKNPSKEERETLVEECNRAECIQRGVSPSQAQGLGSNLVTE
VRVYNWFANRRKEEA
3D structure
PDB8pi9 Molecular mechanism of HNF-1A-mediated HNF4A gene regulation and promoter-driven HNF4A-MODY diabetes.
ChainA
Resolution2.8 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A P129 Q130 R131 Q141 S145 Y265 R272 K273 P37 Q38 R39 Q49 S53 Y154 R161 K162
BS02 dna A N140 S142 H143 Q146 P153 M154 K155 K158 R203 F204 K205 W206 R263 N266 N270 N48 S50 H51 Q54 P61 M62 K63 K66 R92 F93 K94 W95 R152 N155 N159
External links
PDB RCSB:8pi9, PDBe:8pi9, PDBj:8pi9
PDBsum8pi9
PubMed38855865
UniProtP20823|HNF1A_HUMAN Hepatocyte nuclear factor 1-alpha (Gene Name=HNF1A)

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