Structure of PDB 8pi8 Chain A

Receptor sequence

>8pi8A (length=174) Species: 9606 (Homo sapiens) [Search protein sequence]

ILKELENLSPEEAAHQKAVVETLLQEDPWRVAKMVKSYLQQHNIPQREVV
DTTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREVAQQFTHAGRRN
RFKWGPASQQILFQAYERQKNPSKEERETLVEECNRAECIQRGVSPSQAQ
GLGSNLVTEVRVYNWFANRRKEEA

3D structure

PDB

8pi8 Molecular mechanism of HNF-1A-mediated HNF4A gene regulation and promoter-driven HNF4A-MODY diabetes.

Chain

Resolution

2.3 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	P129 Q130 R131 Q141 S142 S145 Q146 N149 K150 R203 Y265 R272 K273	P45 Q46 R47 Q57 S58 S61 Q62 N65 K66 R101 Y163 R170 K171
BS02	dna	A	N140 S142 H143 P153 M154 K155 K158 R203 K205 W206 R263 N270	N56 S58 H59 P69 M70 K71 K74 R101 K103 W104 R161 N168

External links

PDB	RCSB:8pi8, PDBe:8pi8, PDBj:8pi8
PDBsum	8pi8
PubMed	38855865
UniProt	P20823\|HNF1A_HUMAN Hepatocyte nuclear factor 1-alpha (Gene Name=HNF1A)

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