Structure of PDB 8pi7 Chain A

Receptor sequence

>8pi7A (length=168) Species: 9606 (Homo sapiens) [Search protein sequence]

ENLSPEEAAHQKAVVETLLQEDPWRVAKMVKSYLQQHNIPQREVVDTTGL
NQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREVAQQFTHAGNRFKWGPA
SQQILFQAYERQKNPSKEERETLVEECNRAECIQRGVSPSQAQGLGSNLV
TEVRVYNWFANRRKEEAF

3D structure

PDB

8pi7 Molecular mechanism of HNF-1A-mediated HNF4A gene regulation and promoter-driven HNF4A-MODY diabetes.

Chain

Resolution

3.2 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	P129 Q130 R131 Q141 S142 S145 Q146 N149 K205 Y265 R272 K273	P40 Q41 R42 Q52 S53 S56 Q57 N60 K96 Y156 R163 K164
BS02	dna	A	S142 H143 K155 K158 R203 F204 W206 R263 N270	S53 H54 K66 K69 R94 F95 W97 R154 N161

External links

PDB	RCSB:8pi7, PDBe:8pi7, PDBj:8pi7
PDBsum	8pi7
PubMed	38855865
UniProt	P20823\|HNF1A_HUMAN Hepatocyte nuclear factor 1-alpha (Gene Name=HNF1A)

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