Structure of PDB 8pi3 Chain A

Receptor sequence
>8pi3A (length=219) Species: 9606 (Homo sapiens) [Search protein sequence]
RILPDSVDWREKGCVTEVKDQGSCGACWAFSAVGALEAQLKLKTGKLVSL
SAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQK
CQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLY
RSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRM
ARNKGNHCGIASFPSYPEI
3D structure
PDB8pi3 Antibody-peptide conjugates deliver covalent inhibitors blocking oncogenic cathepsins.
ChainA
Resolution1.73 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.22.27: cathepsin S.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A S135 C136 G137 C139 N181 G182 G183 F184 M185 V276 N277 F325 S23 C24 G25 C27 N69 G70 G71 F72 M73 V164 N165 F213
External links
PDB RCSB:8pi3, PDBe:8pi3, PDBj:8pi3
PDBsum8pi3
PubMed38811854
UniProtP25774|CATS_HUMAN Cathepsin S (Gene Name=CTSS)

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