Structure of PDB 8pg0 Chain A

Receptor sequence
>8pg0A (length=511) Species: 9606 (Homo sapiens) [Search protein sequence]
GFKMFLAALSFSYIAKALGGIIMKISITQIERRFDISSSLAGLIDGSFEI
GNLLVIVFVSYFGLHRPKLIGIGCLLMGTGSILTSLPHFFMGYYRYHMWI
YVFMGNMLRGIGETPIVPLGISYIDDFALYLGSLNAIGMIGPVIGFALGS
LFAKMYVDIGYVDLSTIRITPKDSRWVGAWWLGFLVSGLFSIISSIPFFF
GFFQSLKSILTNPLYVIFLLLTLLQVSSFIGSFTYVFKYMEQQYGQSASH
ANFLLGIITIPTVATGMFLGGFIIKKFKLSLVGIAKFSFLTSMISFLFQL
LYFPLICESKSVAGLTLTYDGNNSVHVDVPLSYCNSECNCDESQWEPVCG
NNGITYLSPCLAGCKSSSGHTVFYNCSCVESAHLGECPRDNTCTRKFFIY
VAIQVINSLFSATGGTTFILLTVKIVQPELKALAMGFQSMVIRTLGGILA
PIYFGALIDKTCMKWSTQGACRIYNSVFFGRVYLGLSIALRFPALVLYIV
FIFAMKKKFQG
3D structure
PDB8pg0 Structure of human drug transporters OATP1B1 and OATP1B3.
ChainA
Resolution2.97 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BCT A R58 H115 V235 R33 H88 V157
BS02 CLR A I396 F410 L413 I273 F287 L290
BS03 CLR A S85 F325 L570 G573 F574 M577 S60 F202 L433 G436 F437 M440
Gene Ontology
Molecular Function
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0008514 organic anion transmembrane transporter activity
GO:0015125 bile acid transmembrane transporter activity
GO:0015347 sodium-independent organic anion transmembrane transporter activity
GO:0022857 transmembrane transporter activity
Biological Process
GO:0006805 xenobiotic metabolic process
GO:0006811 monoatomic ion transport
GO:0006869 lipid transport
GO:0010466 negative regulation of peptidase activity
GO:0015711 organic anion transport
GO:0015721 bile acid and bile salt transport
GO:0042167 heme catabolic process
GO:0043252 sodium-independent organic anion transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0009925 basal plasma membrane
GO:0016020 membrane
GO:0016323 basolateral plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8pg0, PDBe:8pg0, PDBj:8pg0
PDBsum8pg0
PubMed37723174
UniProtQ9NPD5|SO1B3_HUMAN Solute carrier organic anion transporter family member 1B3 (Gene Name=SLCO1B3)

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