Structure of PDB 8pfz Chain A

Receptor sequence
>8pfzA (length=410) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence]
RRRVVITGMGMLSPLGLDVPSSWEGILAGRSGIAPIEHMDLSAYSTRFGG
SVKGFNVEEYLSAKEARKLDLFIQYGLAASFQAVRDSGLEVTDANRERIG
VSMGSGIGGLTNIENNCRSLFEQGPRRISPFFVPGSIINMVSGFLSIHLG
LQGPNYALTTAATTGTHSIGMAARNIAYGEADVMVAGGSEMAACGLGLGG
FGAARALSTRNDEPTRASRPWDRDRDGFVLSDGSGALVLEELEHARARGA
RIYAELVGFGMSGDAFHMTAPPEDGAGAARCMKNALRDAGLDPRQVDYIN
AHGTSTPAGDIAEIAAVKSVFGEHAHALSMSSTKSMTGHLLGAAGAVEAI
FSVLALRDQVAPPTINLDNPDEGCDLDLVAHEAKPRKIDVALSNSFGFGG
TNGTLVFRRF
3D structure
PDB8pfz New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion
ChainA
Resolution1.78 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.179: beta-ketoacyl-[acyl-carrier-protein] synthase II.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YQI A P273 G311 A314 F398 G399 P271 G309 A312 F396 G397
Gene Ontology
Molecular Function
GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity
GO:0016746 acyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
GO:0046872 metal ion binding
Biological Process
GO:0006633 fatty acid biosynthetic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8pfz, PDBe:8pfz, PDBj:8pfz
PDBsum8pfz
PubMed
UniProtG3XDA2

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