Structure of PDB 8pfo Chain A

Receptor sequence
>8pfoA (length=419) Species: 9606 (Homo sapiens) [Search protein sequence]
DDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEEARDNVAVMA
TGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQS
ANVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCIS
EWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQ
ITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSHWEFEGPTIIYCPSRK
MTQQVTGELAKLNLSCGTYHAGMSFSTAKDIHHRFVRDEIQCVIATIAFG
MGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINL
NRHLLTEIRNAKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKA
SLGIMGTEKCCDNCRSALD
3D structure
PDB8pfo A WRN inhibitor shows anti-tumor efficacy in MSI-high tumor models
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
5.6.2.4: DNA 3'-5' helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C908 C935 C936 C939 C383 C410 C411 C414
BS02 YHC A A706 I725 C727 R732 L737 M826 G827 Y849 Q850 I852 G853 R854 R857 R910 I913 A182 I201 C203 R208 L213 M301 G302 Y324 Q325 I327 G328 R329 R332 R385 I388
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004386 helicase activity
GO:0005524 ATP binding
Biological Process
GO:0006310 DNA recombination

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Molecular Function
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Biological Process
External links
PDB RCSB:8pfo, PDBe:8pfo, PDBj:8pfo
PDBsum8pfo
PubMed38658754
UniProtQ14191|WRN_HUMAN Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (Gene Name=WRN)

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