Structure of PDB 8pfl Chain A

Receptor sequence
>8pflA (length=422) Species: 9606 (Homo sapiens) [Search protein sequence]
DDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEEARDNVAVMA
TGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSA
QSANVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHC
ISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRN
PQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCP
SRKMTQQVTGELAKLNLSCGTYHAGMSFSTAKDIHHRFVRDEIQCVIATI
AFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPAD
INLNRHLLTEIRNAKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQV
QKASLGIMGTEKCCDNCRSALD
3D structure
PDB8pfl A WRN inhibitor shows anti-tumor efficacy in MSI-high tumor models
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
5.6.2.4: DNA 3'-5' helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C908 C935 C936 C939 C386 C413 C414 C417
BS02 YH8 A A706 I725 C727 F730 R732 L737 M826 G827 Y849 Q850 I852 G853 R854 R857 A184 I203 C205 F208 R210 L215 M304 G305 Y327 Q328 I330 G331 R332 R335
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004386 helicase activity
GO:0005524 ATP binding
Biological Process
GO:0006310 DNA recombination

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Molecular Function
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Biological Process
External links
PDB RCSB:8pfl, PDBe:8pfl, PDBj:8pfl
PDBsum8pfl
PubMed38658754
UniProtQ14191|WRN_HUMAN Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (Gene Name=WRN)

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