Structure of PDB 8pdu Chain A

Receptor sequence

>8pduA (length=1022) Species: 7668 (Strongylocentrotus purpuratus)

AHAPKVIVFISGSCLFGAISRSLFKKLPIPYTVVLLILGAILGVVASNVP
LVEEHTRDVAHMDPHVLLQIFLPVLIFESAFAMDVHTFMRSFSQVCILAL
FGLVVASVLTAVLAMNLFNYNWNFSEAMMFGAIMSATDPVAVVALLKDLG
ASKQLGTIIEGESLLNDGCAIVIFNVFMKMVFFPQLTSTVGQNVLYFLQV
AVAGPLWGYAVAKVTVFFLSHIFNDALVEITITLAATYLTYYIGDIWLEV
SGVLAVVVLGLIVNAEKTSISPEVEVFLHRFWEMLAYLANTLIFMMVGVV
VTQKALVAVDKMDWFYLIILYLAITIIRGMVISLFSPILSRIGYGLTWRN
AVIMTWGGLRGAVGLALALVVENLAGNDVIGSKFLFHTAGIVVLTLVINA
TTIQTLLRILGMSDISIPKRLAMAGAVRRIHEGQNRTLNMLKSDRFLADA
DWDIATAACEISDPYSSPREFADMMEEARLRMLKAEKISYWKQFEHGMLA
REALRLLVQHAEVAADEKDQFILVDDLKKSWQIKGIYPWLKRKLEDLISE
KKIAKLMYKICHHMAFEVTINIAIVLNIVPIIMEFVVQDKMALQKIEDAL
RISNYVFFVIYAIEAIVKILGLGRHYIVSHWNKFDAFILVVALVDIIIKV
VKLFRLLRGLRMLRLTKALIPKLILVVNGKINNQLSLGYDVGKGYIIGEE
EVGKIIDRMVDNKKILRELKHISETGRLQVVKELGLLQREHPGIAVSVKT
RQAIRTILNHSRETIHELQGAGLLDEMEAHKLELTVEIKMKRLMNAPSSI
PPPPPENLLKNVSWLAGDMKLIDFIKARASLLHFDYGEVIVREGDESDGL
FLIVSGLVKLYFEDYLTVGNVIGEMGVLTKKPRNATVTCETTVQVYFITA
EDMNIAIDTFTLYPSLEYRLWRVVAIRIATPLIMEQMAFQGWTQEKVKLH
LERGYLVDLAESHFQFNIDATLEDVILINGTAYNAHTREEIRSPCLISRT
VHKLTFQYTATEEPRLFVVRNA

3D structure

• PDB: 8pdu Structures of a sperm-specific solute carrier gated by voltage and cAMP.
• Chain: A
• Resolution: 3.22 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	PCG	A	L1008 G1043 M1045 R1053 N1054 A1055 R1097	L860 G873 M875 R883 N884 A885 R927

Gene Ontology

Molecular Function

• GO:0015297 antiporter activity
• GO:0015385 sodium:proton antiporter activity

Biological Process

• GO:0006812 monoatomic cation transport
• GO:0055085 transmembrane transport
• GO:1902600 proton transmembrane transport

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:8pdu, PDBe:8pdu, PDBj:8pdu
• PDBsum: 8pdu
• PubMed: 37880361
• UniProt: A3RL54|SL9C1_STRPU Sperm-specific sodium:proton exchanger (Gene Name=SLC9C1)