Structure of PDB 8pd9 Chain A

Receptor sequence

>8pd9A (length=1024) Species: 7668 (Strongylocentrotus purpuratus)

AHAPKVIVFISGSCLFGAISRSLFKKLPIPYTVVLLILGAILGVVASNVP
LVEEHTRDVAHMDPHVLLQIFLPVLIFESAFAMDVHTFMRSFSQVCILAL
FGLVVASVLTAVLAMNLFNYNWNFSEAMMFGAIMSATDPVAVVALLKDLG
ASKQLGTIIEGESLLNDGCAIVIFNVFMKMVFFPQLTSTVGQNVLYFLQV
AVAGPLWGYAVAKVTVFFLSHIFNDALVEITITLAATYLTYYIGDIWLEV
SGVLAVVVLGLIVNAEKTSISPEVEVFLHRFWEMLAYLANTLIFMMVGVV
VTQKALVAVDKMDWFYLIILYLAITIIRGMVISLFSPILSRIGYGLTWRN
AVIMTWGGLRGAVGLALALVVENLAGNDVIGSKFLFHTAGIVVLTLVINA
TTIQTLLRILGMSDISIPKRLAMAGAVRRIHEGQNRTLNMLKSDRFLADA
DWDIATAACEISDPYSPSPREFADMMEEARLRMLKAEKISYWKQFEHGML
AREALRLLVQHAEVAADEKDQFILVDDLKKSWQIKGIYPWLKRKLEDLIS
HHMAFEVTINIAIVLNIVPIIMEFVVQDKMALQKIEDALRISNYVFFVIY
AIEAIVKILGLGRHYIVSHWNKFDAFILVVALVDIIIAETSSIKVVKLFR
LLRGLRMLRLTKALIPKLILVVNGKINNQLSLGYDVGKGYIIGEEEVGKI
IDRMVDNKKILRELKHISETGRLQVVKELGLLQREHPGIAVSVKTRQAIR
TILNHSRETIHELQGAGLLDEMEAHKLELTVEIKMKRLMNAPSSIPPPPP
ENLLKNVSWLAGDMKLIDFIKARASLLHFDYGEVIVREGDESDGLFLIVS
GLVKLYGKSVFEDYLTVGNVIGEMGVLTKKPRNATVTCETTVQVYFITAE
DMNIAIDTFTLYPSLEYRLWRVVAIRIATPLIMEQMAFQGWTQEKVKLHL
ERGYLVDLAESHFQFNIDATLEDVILINGTAYNAHTREEIRSPCLISRTV
HKLTFQYTATEEPRLFVVRNAEYN

3D structure

• PDB: 8pd9 Structures of a sperm-specific solute carrier gated by voltage and cAMP.
• Chain: A
• Resolution: 3.6 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CMP	A	L1008 F1032 G1043 G1046 R1053 N1054 R1097	L855 F861 G872 G875 R882 N883 R926

Gene Ontology

Molecular Function

• GO:0015297 antiporter activity
• GO:0015385 sodium:proton antiporter activity

Biological Process

• GO:0006812 monoatomic cation transport
• GO:0055085 transmembrane transport
• GO:1902600 proton transmembrane transport

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:8pd9, PDBe:8pd9, PDBj:8pd9
• PDBsum: 8pd9
• PubMed: 37880361
• UniProt: A3RL54|SL9C1_STRPU Sperm-specific sodium:proton exchanger (Gene Name=SLC9C1)