Structure of PDB 8pc4 Chain A

Receptor sequence
>8pc4A (length=332) Species: 9606 (Homo sapiens) [Search protein sequence]
SKKGKDGRFVNPWPTWKNPSIPNVLRWLIMEKDHSSVPSSKEELDKELPV
LKPYFITNPEEAGVREAGLRVTWLGHATVMVEMDELIFLTDPIFSSRASP
SQYMGPKRFRRSPCTISELPPIDAVLISHNHYDHLDYNSVIALNERFGNE
LRWFVPLGLLDWMQKCGCENVIELDWWEENCVPGHDKVTFVFTPSQHWCK
RTLMDDNKVLWGSWSVLGPWNRFFFAGDTGYCPAFEEIGKRFGPFDLAAI
PIGAYEPRWFMKYQHVDPEEAVRIHTDVQTKKSMAIHWGTFALANEHYLE
PPVKLNEALERYGLNAEDFFVLKHGESRYLNN
3D structure
PDB8pc4 MEMBRANE TARGET COMPLEX 1
ChainA
Resolution2.85 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H185 H187 H253 D284 H129 H131 H197 D228
BS02 ZN A D189 H190 D284 H343 D133 H134 D228 H287
BS03 DXC A Y193 W218 C222 Y137 W162 C166
BS04 DXC A W218 R257 W162 R201
BS05 DXC A K88 Y159 M160 K32 Y103 M104
BS06 DXC A L81 R82 L25 R26
BS07 HCZ A S151 S152 S95 S96
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0032052 bile acid binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity
Biological Process
GO:0001523 retinoid metabolic process
GO:0001659 temperature homeostasis
GO:0009395 phospholipid catabolic process
GO:0048874 host-mediated regulation of intestinal microbiota composition
GO:0050729 positive regulation of inflammatory response
GO:0070291 N-acylethanolamine metabolic process
GO:0070292 N-acylphosphatidylethanolamine metabolic process
GO:0090336 positive regulation of brown fat cell differentiation
Cellular Component
GO:0000139 Golgi membrane
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005769 early endosome
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0030868 smooth endoplasmic reticulum membrane
GO:0031901 early endosome membrane
GO:0042622 photoreceptor outer segment membrane
GO:0042734 presynaptic membrane
GO:0045211 postsynaptic membrane
GO:0070062 extracellular exosome
GO:0098686 hippocampal mossy fiber to CA3 synapse
GO:0098793 presynapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8pc4, PDBe:8pc4, PDBj:8pc4
PDBsum8pc4
PubMed
UniProtQ6IQ20|NAPEP_HUMAN N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D (Gene Name=NAPEPLD)

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