Structure of PDB 8pb5 Chain A

Receptor sequence
>8pb5A (length=320) Species: 181762 (Psilocybe cubensis) [Search protein sequence]
HMASENLYFQGMHIRNPYRTPIDYQALSEAFPPLKPFVSVNADGTSSVDL
TIPEAQRAFTAALLHRDFGLTMTIPEDRLCPTVPNRLNYVLWIEDIFNYT
NKTLGLSDDRPIKGVDIGTGASAIYPMLACARFKAWSMVGTEVERKCIDT
ARLNVVANNLQDRLSILETSIDGPILVPIFEATEEYEYEFTMCNPPFYDG
AADMQTSDAAKGFGFGVGAPHSGTVIEMSTEGGESAFVAQMVRESLKLRT
RCRWYTSNLGKLKSLKEIVGLLKELEISNYAINEYVQGSTRRYAVAWSFT
DIQLPEELSRPSNPELSSLF
3D structure
PDB8pb5 Methyl transfer in psilocybin biosynthesis
ChainA
Resolution0.89 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SFG A L68 R75 G107 T108 E131 V132 T158 N183 I215 E216 F226 L79 R86 G118 T119 E142 V143 T169 N194 I226 E227 F237
BS02 XP6 A R75 N183 P184 F186 Y187 A199 F202 G203 H210 M217 R281 R86 N194 P195 F197 Y198 A210 F213 G214 H221 M228 R292
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0052907 23S rRNA (adenine(1618)-N(6))-methyltransferase activity
GO:0140381 4-hydroxytryptamine 4-phosphate methyltransferase activity
Biological Process
GO:0032259 methylation
GO:0070475 rRNA base methylation
GO:0140380 psilocybin biosynthetic process
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8pb5, PDBe:8pb5, PDBj:8pb5
PDBsum8pb5
PubMed38548735
UniProtP0DPA9|PSIM_PSICU Psilocybin synthase (Gene Name=psiM)

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