Structure of PDB 8pb3 Chain A

Receptor sequence
>8pb3A (length=310) Species: 181762 (Psilocybe cubensis) [Search protein sequence]
GMHIRNPYRTPIDYQALSEAFPPLKPFVSVNADGTSSVDLTIPEAQRAFT
AALLHRDFGLTMTIPEDRLCPTVPNRLNYVLWIEDIFNYTNKTLGLSDDR
PIKGVDIGTGASAIYPMLACARFKAWSMVGTEVERKCIDTARLNVVANNL
QDRLSILETSIDGPILVPIFEATEEYEYEFTMCNPPFYDGAADMQTSDAA
KGFGFGVGAPHSGTVIEMSTEGGESAFVAQMVRESLKLRTRCRWYTSNLG
KLKSLKEIVGLLKELEISNYAINEYVQGSTRRYAVAWSFTDIQLPEELSR
PSNPELSSLF
3D structure
PDB8pb3 Methyl transfer in psilocybin biosynthesis
ChainA
Resolution1.18 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A L68 R75 G107 T108 E131 V132 T158 N183 P185 I215 E216 F226 L69 R76 G108 T109 E132 V133 T159 N184 P186 I216 E217 F227
BS02 XP6 A R75 N183 P184 F186 Y187 A199 F202 G203 H210 M217 R281 R76 N184 P185 F187 Y188 A200 F203 G204 H211 M218 R282
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0052907 23S rRNA (adenine(1618)-N(6))-methyltransferase activity
GO:0140381 4-hydroxytryptamine 4-phosphate methyltransferase activity
Biological Process
GO:0032259 methylation
GO:0070475 rRNA base methylation
GO:0140380 psilocybin biosynthetic process
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8pb3, PDBe:8pb3, PDBj:8pb3
PDBsum8pb3
PubMed38548735
UniProtP0DPA9|PSIM_PSICU Psilocybin synthase (Gene Name=psiM)

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