Structure of PDB 8paw Chain A

Receptor sequence

>8pawA (length=272) Species: 9606 (Homo sapiens) [Search protein sequence]

TKQPEEVFDVLEKLGESVYKAIHKETGQIVAIKQVPVESDLQEIIKEISI
MQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEI
ATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTD
TMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYAD
IHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLL
QHPFVRSAKGVSILRDLINEAM

3D structure

PDB

8paw Identification and optimization of Azaindole based MAP4K1 Inhibitors and the discovery of BAY-405

Chain

Resolution

2.14 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ASP	A	N295 E296 M298	N269 E270 M272
BS02	XQL	A	L36 G37 V44 A57 K59 E73 M102 E103 C105 D112 R115 L156	L14 G15 V18 A31 K33 E47 M76 E77 C79 D86 R89 L130

External links

PDB	RCSB:8paw, PDBe:8paw, PDBj:8paw
PDBsum	8paw
PubMed
UniProt	Q13043\|STK4_HUMAN Serine/threonine-protein kinase 4 (Gene Name=STK4)

[Back to BioLiP]