Structure of PDB 8pav Chain A

Receptor sequence

>8pavA (length=273) Species: 9606 (Homo sapiens) [Search protein sequence]

TKQPEEVFDVLEKLGEGSVYKAIHKETGQIVAIKQVPVESDLQEIIKEIS
IMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDE
IATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLT
DTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYA
DIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQL
LQHPFVRSAKGVSILRDLINEAM

3D structure

PDB

8pav Identification and optimization of Azaindole based MAP4K1 Inhibitors and the discovery of BAY-405

Chain

Resolution

1.9 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	XOZ	A	L36 V44 A57 M102 E103 C105 D112 R115 L156	L14 V19 A32 M77 E78 C80 D87 R90 L131

External links

PDB	RCSB:8pav, PDBe:8pav, PDBj:8pav
PDBsum	8pav
PubMed
UniProt	Q13043\|STK4_HUMAN Serine/threonine-protein kinase 4 (Gene Name=STK4)

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