Structure of PDB 8pas Chain A

Receptor sequence

>8pasA (length=269) Species: 9606 (Homo sapiens) [Search protein sequence]

IFNRDPRDHYDLLQRLGGGGEVFKARDSGDLVALKMVKMEPDDDVSTLQK
EILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSE
LQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISTP
YWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFL
MTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQ
PGLNRGLILDLLDKLKNPG

3D structure

PDB

8pas Identification and optimization of Azaindole based MAP4K1 Inhibitors and the discovery of BAY-405

Chain

Resolution

2.7 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	XOH	A	L23 V31 A44 M91 E92 C94 D101 Q104 L144 A154	L16 V22 A33 M80 E81 C83 D90 Q93 L133 A143

External links

PDB	RCSB:8pas, PDBe:8pas, PDBj:8pas
PDBsum	8pas
PubMed
UniProt	Q92918\|M4K1_HUMAN Mitogen-activated protein kinase kinase kinase kinase 1 (Gene Name=MAP4K1)

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