Structure of PDB 8par Chain A

Receptor sequence

>8parA (length=268) Species: 9606 (Homo sapiens) [Search protein sequence]

DIFNRDPRDHYDLLQRLGGGTYGEVFKARDDLVALKMVKMEPDDDVSTLQ
KEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLS
ELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGGTP
YWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFL
MTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQ
PGLNRGLILDLLDKLKNP

3D structure

PDB

8par Identification and optimization of Azaindole based MAP4K1 Inhibitors and the discovery of BAY-405

Chain

Resolution

2.0 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	XON	A	L23 G25 Y28 V31 A44 E92 C94 D101 L144	L17 G19 Y22 V25 A34 E82 C84 D91 L134

External links

PDB	RCSB:8par, PDBe:8par, PDBj:8par
PDBsum	8par
PubMed
UniProt	Q92918\|M4K1_HUMAN Mitogen-activated protein kinase kinase kinase kinase 1 (Gene Name=MAP4K1)

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