Structure of PDB 8p9i Chain A

Receptor sequence
>8p9iA (length=124) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELP
3D structure
PDB8p9i Crystal structure of the first bromodomain of human BRD4 in complex with the dual BET/HDAC inhibitor NB462
ChainA
Resolution1.23 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 X8T A W81 P82 F83 V87 L92 N140 W40 P41 F42 V46 L51 N99
External links
PDB RCSB:8p9i, PDBe:8p9i, PDBj:8p9i
PDBsum8p9i
PubMed38291964
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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