Structure of PDB 8p9h Chain A

Receptor sequence
>8p9hA (length=125) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPT
3D structure
PDB8p9h Crystal structure of the first bromodomain of human BRD4 in complex with the dual BET/HDAC inhibitor NB437
ChainA
Resolution1.19 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 X9C A W81 P82 V87 L92 N140 I146 W40 P41 V46 L51 N99 I105
External links
PDB RCSB:8p9h, PDBe:8p9h, PDBj:8p9h
PDBsum8p9h
PubMed38291964
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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