Structure of PDB 8p9b Chain A

Receptor sequence
>8p9bA (length=263) Species: 9606 (Homo sapiens) [Search protein sequence]
STDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPG
HIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSH
IHKRRHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVS
PVKICDFSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPF
VGRCCPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQR
LSAAQVLQHPWVQ
3D structure
PDB8p9b Crystal Structure of Mnk2-D228G in complex with Tinodasertib
ChainA
Resolution2.59 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C299 C311 C314 C204 C205 C208
BS02 X8K A L90 V98 A111 L143 F159 M162 G165 E209 L212 C225 L20 V28 A41 L73 F89 M92 G95 E139 L142 C155
External links
PDB RCSB:8p9b, PDBe:8p9b, PDBj:8p9b
PDBsum8p9b
PubMed
UniProtQ9HBH9|MKNK2_HUMAN MAP kinase-interacting serine/threonine-protein kinase 2 (Gene Name=MKNK2)

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