Structure of PDB 8p81 Chain A

Receptor sequence
>8p81A (length=320) Species: 9606 (Homo sapiens) [Search protein sequence]
ESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKE
GFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEY
MDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNI
LLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTP
AIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIK
LPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTL
QSDFLKDVELSKMAPPDLPH
3D structure
PDB8p81 The reversible inhibitor SR-4835 binds Cdk12/Cyclin K in a non-canonical G-loop conformation
ChainA
Resolution2.68 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.22: cyclin-dependent kinase.
2.7.11.23: [RNA-polymerase]-subunit kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 RMF A I733 G734 F813 Y815 M816 D817 H818 D819 S863 L866 D877 I18 G19 F98 Y100 M101 D102 H103 D104 S148 L151 D162
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8p81, PDBe:8p81, PDBj:8p81
PDBsum8p81
PubMed38016516
UniProtQ9NYV4|CDK12_HUMAN Cyclin-dependent kinase 12 (Gene Name=CDK12)

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