Structure of PDB 8p7p Chain A

Receptor sequence
>8p7pA (length=330) Species: 227321 (Aspergillus nidulans FGSC A4) [Search protein sequence]
GSVSKANVPKIDVSPLFGDDQAAKMRVAQQIDAASRDTGFFYAVNHGINV
QRLSQKTKEFHMSITPEEKWDLAIRAYNKEHQDQVRAGYYLSIPGKKAVE
SFCYLNPNFTPDHPRIQAKTPTHEVNVWPDETKHPGFQDFAEQYYWDVFG
LSSALLKGYALALGKEENFFARHFKPDDTLASVVLIRYPYLDPYPEAAIK
TAADGTKLSFEWHEDVSLITVLYQSNVQNLQVETAAGYQDIEADDTGYLI
NCGSYMAHLTNNYYKAPIHRVKWVNAERQSLPFFVNLGYDSVIDPFDPRE
PNGKSDREPLSYGDYLQNGLVSLINKNGQT
3D structure
PDB8p7p Isopenicillin N synthase in complex with Fe and Aad-Val-[(R)-1-amino-2-methylpropane-1-sulfonic acid]
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.21.3.1: isopenicillin-N synthase.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 X2R A R87 C104 S183 I187 Y189 F211 H214 D216 V272 F285 L324 R86 C103 S182 I186 Y188 F210 H213 D215 V271 F284 L323
BS02 FE A H214 D216 H270 H213 D215 H269
Gene Ontology
Molecular Function
GO:0016216 isopenicillin-N synthase activity
GO:0016491 oxidoreductase activity
GO:0031418 L-ascorbic acid binding
GO:0046872 metal ion binding
Biological Process
GO:0017000 antibiotic biosynthetic process
GO:0042318 penicillin biosynthetic process
GO:0044283 small molecule biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:8p7p, PDBe:8p7p, PDBj:8p7p
PDBsum8p7p
PubMed
UniProtP05326|IPNA_EMENI Isopenicillin N synthase (Gene Name=ipnA)

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