Structure of PDB 8p7j Chain A

Receptor sequence
>8p7jA (length=277) Species: 9606 (Homo sapiens) [Search protein sequence]
SMEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQK
RLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVI
DKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVK
MCDFGISGYLKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFP
YDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYP
ELMQHPFFTLHESKGTDVASFVKLILG
3D structure
PDB8p7j Crystal structure of MAP2K6 with a covalent compound GCL96
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.12.2: mitogen-activated protein kinase kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 X3K A Y64 V67 A80 L131 M132 L186 C196 Y20 V23 A36 L87 M88 L142 C152
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8p7j, PDBe:8p7j, PDBj:8p7j
PDBsum8p7j
PubMed
UniProtP52564|MP2K6_HUMAN Dual specificity mitogen-activated protein kinase kinase 6 (Gene Name=MAP2K6)

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