Structure of PDB 8p5i Chain A

Receptor sequence
>8p5iA (length=269) Species: 9606 (Homo sapiens) [Search protein sequence]
TETVGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQ
TLLGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAM
RTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPANPNSIRV
KIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIV
YQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPAATSAPLRQLLLALLQR
NHKDRMDFDEFFHHPFLDA
3D structure
PDB8p5i Crystal structures of ULK1 in complex with KCGS compounds
ChainA
Resolution1.829 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WYX A V30 K46 M92 E93 Y94 C95 L145 V23 K39 M85 E86 Y87 C88 L138
BS02 MG A E191 Y198 D199 H263 E180 Y187 D188 H252
BS03 MG A H136 D165 F166 F168 H129 D154 F155 F157
External links
PDB RCSB:8p5i, PDBe:8p5i, PDBj:8p5i
PDBsum8p5i
PubMed
UniProtO75385|ULK1_HUMAN Serine/threonine-protein kinase ULK1 (Gene Name=ULK1)

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