Structure of PDB 8p47 Chain A

Receptor sequence
>8p47A (length=330) Species: 227321 (Aspergillus nidulans FGSC A4) [Search protein sequence]
GSVSKANVPKIDVSPLFGDDQAAKMRVAQQIDAASRDTGFFYAVNHGINV
QRLSQKTKEFHMSITPEEKWDLAIRAYNKEHQDQVRAGYYLSIPGKKAVE
SFCYLNPNFTPDHPRIQAKTPTHEVNVWPDETKHPGFQDFAEQYYWDVFG
LSSALLKGYALALGKEENFFARHFKPDDTLASVVLIRYPYLDPYPEAAIK
TAADGTKLSFEWHEDVSLITVLYQSNVQNLQVETAAGYQDIEADDTGYLI
ACGSYMAHLTNNYYKAPIHRVKWVNAERQSLPFFVNLGYDSVIDPFDPRE
PNGKSDREPLSYGDYLQNGLVSLINKNGQT
3D structure
PDB8p47 IPNS variant N252A in complex with Fe and ACV under anaerobic conditions
ChainA
Resolution1.56 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 1.21.3.1: isopenicillin-N synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ACV A R87 C104 S183 I187 Y189 H214 D216 S281 F285 R86 C103 S182 I186 Y188 H213 D215 S280 F284
BS02 FE A H214 D216 H270 H213 D215 H269
Gene Ontology
Molecular Function
GO:0016216 isopenicillin-N synthase activity
GO:0016491 oxidoreductase activity
GO:0031418 L-ascorbic acid binding
GO:0046872 metal ion binding
Biological Process
GO:0017000 antibiotic biosynthetic process
GO:0042318 penicillin biosynthetic process
GO:0044283 small molecule biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8p47, PDBe:8p47, PDBj:8p47
PDBsum8p47
PubMed
UniProtP05326|IPNA_EMENI Isopenicillin N synthase (Gene Name=ipnA)

[Back to BioLiP]