Structure of PDB 8p2d Chain A

Receptor sequence
>8p2dA (length=542) Species: 165179 (Segatella copri) [Search protein sequence]
DTPAGMMMKFASETTKPFVDDYLLSEDVRDAVMHNYIHIHDKDYYPTKSL
TCVQHPLDVILNHGFTAGHGSSRPAKRIETAAVLACISLETCQNEMHGGQ
AIPAFDFYLAPYVRMSYQEEVKNLEKLTGEDLSNLYDAPIDDYIEKPLDG
LQGRERLEQHAINKTVNRVHQAMEAFIHNMNTIVFSSINYGTDTSAEGRC
IMREILQSTYQGVGNGETAIFPIQIWKKKRGVNYLPEDRNYDLYKLACKV
TARRFFPNFLNLDATFNQNEKWRADDPERYKWEIATMGCRTRVFEDRWGE
KTSIARGNLSFSTINIVKLAIECMGIENEKQRIDMFFAKLDNILDITAKQ
LDERFQFQKTAMAKQFPLLMKYLWVGAENLKPEETIESVINHGTLGIGFI
GLAECLVALIGKHHGESEKAQELGLKIITYMRDRANEFSEQYHHNYSILA
TPAEGLSGKFTKKDRKQFGVIPGVTDRDYYTNSNHVPVYYKCTALKKAQI
EAPYHDLTRGGHIFYVEINPSVIESVVDMMDKYNMGYGSVNH
3D structure
PDB8p2d Activity modulation in anaerobic ribonucleotide reductase: nucleotide binding to the ATP-cone mediates long-range order-disorder transitions in the active site
ChainA
Resolution2.59 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.17.4.2: ribonucleoside-triphosphate reductase (thioredoxin).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DTP A S191 R192 P193 A194 K195 R196 T199 V202 S72 R73 P74 A75 K76 R77 T80 V83
BS02 DTP A Q290 H297 N298 Q171 H178 N179
Gene Ontology
Molecular Function
GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0005524 ATP binding
GO:0008998 ribonucleoside-triphosphate reductase (thioredoxin) activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0006260 DNA replication
GO:0009265 2'-deoxyribonucleotide biosynthetic process
Cellular Component
GO:0031250 anaerobic ribonucleoside-triphosphate reductase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8p2d, PDBe:8p2d, PDBj:8p2d
PDBsum8p2d
PubMed38968292
UniProtA0A3E4SF67

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