Structure of PDB 8p29 Chain A

Receptor sequence
>8p29A (length=197) Species: 9606 (Homo sapiens) [Search protein sequence]
GLGTARLQLVEFSAFVEPPQRHLFVHISQPLESVDVRQIYDKFPEKKGGL
RELYDRGPPHAFFLVKFWADLNWSGGFYGVSSQYESLEHMTLTCSSKVCS
FGKQVVEKVETERAQLEDGRFVYRLLRSPMCEYLVNFLHKLRQLPERYMM
NSVLENFTILQVVTNRDTQELLLCTAYVFEVSTSERGAQHHIYRLVR
3D structure
PDB8p29 Development of LM-41 and AF-2112, two flufenamic acid-derived TEAD inhibitors obtained through the replacement of the trifluoromethyl group by aryl rings.
ChainA
Resolution2.06 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WJC A F233 V329 S345 V347 V355 K357 M379 C380 L383 F406 I408 F12 V80 S96 V98 V106 K108 M130 C131 L134 F157 I159
External links
PDB RCSB:8p29, PDBe:8p29, PDBj:8p29
PDBsum8p29
PubMed37770003
UniProtQ15562|TEAD2_HUMAN Transcriptional enhancer factor TEF-4 (Gene Name=TEAD2)

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