Structure of PDB 8p27 Chain A

Receptor sequence
>8p27A (length=544) Species: 165179 (Segatella copri) [Search protein sequence]
DTPAGMMMKFASETTKPFVDDYLLSEDVRDAVMHNYIHIHDKDYYPTKSL
TCVQHPLDVILNHGFTAGHGSSRPAKRIETAAVLACISLETCQNEMHGGQ
AIPAFDFYLAPYVRMSYQEEVKNLEKLTGEDLSNLYDAPIDDYIEKPLDG
LQGRERLEQHAINKTVNRVHQAMEAFIHNMNTIHSVFSSINYGTDTSAEG
RCIMREILQSTYQGVGNGETAIFPIQIWKKKRGVNYLPEDRNYDLYKLAC
KVTARRFFPNFLNLDATFNQNEKWRADDPERYKWEIATMGCRTRVFEDRW
GEKTSIARGNLSFSTINIVKLAIECMGIENEKQRIDMFFAKLDNILDITA
KQLDERFQFQKTAMAKQFPLLMKYLWVGAENLKPEETIESVINHGTLGIG
FIGLAECLVALIGKHHGESEKAQELGLKIITYMRDRANEFSEQYHHNYSI
LATPAEGLSGKFTKKDRKQFGVIPGVTDRDYYTNSNHVPVYYKCTALKKA
QIEAPYHDLTRGGHIFYVEINPSVIESVVDMMDKYNMGYGSVNH
3D structure
PDB8p27 Activity modulation in anaerobic ribonucleotide reductases: nucleotide binding to the ATP-cone mediates long-range order-disorder transitions in the active site
ChainA
Resolution2.73 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.17.4.2: ribonucleoside-triphosphate reductase (thioredoxin).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DTP A R192 R196 T199 V202 R73 R77 T80 V83
BS02 MG A Q290 E293 Q171 E174
BS03 DTP A Q290 H297 Q171 H178
Gene Ontology
Molecular Function
GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0005524 ATP binding
GO:0008998 ribonucleoside-triphosphate reductase (thioredoxin) activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0006260 DNA replication
GO:0009265 2'-deoxyribonucleotide biosynthetic process
Cellular Component
GO:0031250 anaerobic ribonucleoside-triphosphate reductase complex

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Biological Process
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Cellular Component
External links
PDB RCSB:8p27, PDBe:8p27, PDBj:8p27
PDBsum8p27
PubMed38968292
UniProtA0A3E4SF67

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