Structure of PDB 8p23 Chain A

Receptor sequence
>8p23A (length=686) Species: 165179 (Segatella copri) [Search protein sequence]
IQTVVKRDGRIVGFNEQKIMAAIRKAMLHTDKGEDTTLIEQITDHISYKS
QMSVEAIQDAIEMELMKSARKDVAQKYIAYRNQRNIARKAKTRDVFMSIV
NAKNNDITRENANMNADTPAGMMMKFASETTKPFVDDYLLSEDVRDAVMH
NYIHIHDKDYYPTKSLTCVQHPLDVILNHGFPAKRIETAAVLACISLETC
QNEMHGGQAIPAFDFYLAPYVRMSYQEEVKNLEKLTGEDLSNLYDAPIDD
YIEKPLDGLQGRERLEQHAINKTVNRVHQAMEAFIHNMNTIHVVFSSINY
GTDTSAEGRCIMREILQSTYQGVGNGETAIFPIQIWKKKRGVNYLPEDRN
YDLYKLACKVTARRFFPNFLNLDATFNQNEKWRADDPERYKWEIATMGCR
TRVFEDRWGEKTSIARGNLSFSTINIVKLAIECMGIENEKQRIDMFFAKL
DNILDITAKQLDERFQFQKTAMAKQFPLLMKYLWVGAENLKPEETIESVI
NHGTLGIGFIGLAECLVALIGKHHGESEKAQELGLKIITYMRDRANEFSE
QYHHNYSILATPAEGLSGKFTKKDRKQFGVIPGVTDRDYYTNSNHVPVYY
KCTALKKAQIEAPYHDLTRGGHIFYVEIDGDATHNPSVIESVVDMMDKYN
MGYGSVNHNKLQRLVGTTDRWNSGKLAELHDRVTHI
3D structure
PDB8p23 Activity modulation in anaerobic ribonucleotide reductase: nucleotide binding to the ATP-cone mediates long-range order-disorder transitions in the active site
ChainA
Resolution3.17 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 1.17.4.2: ribonucleoside-triphosphate reductase (thioredoxin).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A K19 K26 Y80 Y83 R87 K18 K25 Y77 Y80 R84
BS02 ATP A K7 R8 F15 Y80 R84 R87 K6 R7 F14 Y77 R81 R84
Gene Ontology
Molecular Function
GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0005524 ATP binding
GO:0008998 ribonucleoside-triphosphate reductase (thioredoxin) activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0006260 DNA replication
GO:0009265 2'-deoxyribonucleotide biosynthetic process
Cellular Component
GO:0031250 anaerobic ribonucleoside-triphosphate reductase complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8p23, PDBe:8p23, PDBj:8p23
PDBsum8p23
PubMed38968292
UniProtA0A3E4SF67

[Back to BioLiP]