Structure of PDB 8p1i Chain A

Receptor sequence
>8p1iA (length=1024) Species: 1162296 (Klebsiella pneumoniae subsp. pneumoniae DSM 30104 = JCM 1662 = NBRC 14940) [Search protein sequence]
MPNFFIDRPIFAWVIAIIIMLAGGLSILKLPVAQYPTIAPPAISITAMYP
GADAETVQNTVTQVIEQNMNGIDHLMYMSSNGDSTGTATITLTFESGTDP
DIAQVQVQNKLALATPLLPQEVQQQGISVEKASSSFLMVVGVINTNGTMN
QDDISDYVAANMKDPISRTSGVGDVQLFGSQYAMRIWMDPNKLNNFQLTP
VDVISALKAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRLTNTEEFGNIL
LKVNQDGSQVRLRDVAKIELGGESYDVVAKFNGQPASGLGIKLATGANAL
DTANAIRAELAKMEPFFPSGMKIVYPYDTTPFVKISIHEVVKTLVEAIIL
VFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVL
AIGLLVDDAIVVVENVERVMAEEGLPPKEATRKSMGQIQGALVGIAMVLS
AVFIPMAFFGGSTGAIYRQFSITIVSAMALSVLVALILTPALCATMLKPT
GFFGWFNRMFDKSTHHYTDSVGNILRSTGRYLVLYLIIVVGMAWLFVRLP
SSFLPDEDQGVFLSMAQLPAGATQERTQKVLDEMTNYYLTKEKDNVESVF
AVNGFGFAGRGQNTGIAFVSLKDWSQRPGEENKVEAITARAMGYFSQIKD
AMVFAFNLPAIVELGTATGFDFELIDQGGLGHEKLTQARNQLFGMVAQHP
DVLTGVRPNGLEDTPQFKIDIDQEKAQALGVSISDINTTLGAAWGGSYVN
DFIDRGRVKKVYIMSEAKYRMLPEDIGKWYVRGSDGQMVPFSAFSTSRWE
YGSPRLERYNGLPSLEILGQAAPGKSTGEAMALMEELAGKLPSGIGYDWT
GMSYQERLSGNQAPALYAISLIVVFLCLAALYESWSIPFSVMLVVPLGVV
GALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMEKEGKGL
IEATLEAVRMRLRPILMTSLAFILGVMPLVISSGAGSGAQNAVGTGVMGG
MVTATILAIFFVPVFFVVVRRRFS
3D structure
PDB8p1i Pyridylpiperazine efflux pump inhibitor boosts in vivo antibiotic efficacy against K. pneumoniae.
ChainA
Resolution2.97 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WQW A D408 V411 I438 L442 I445 A446 L943 D408 V411 I438 L442 I445 A446 L934
Gene Ontology
Molecular Function
GO:0015562 efflux transmembrane transporter activity
GO:0022857 transmembrane transporter activity
GO:0042910 xenobiotic transmembrane transporter activity
Biological Process
GO:0042908 xenobiotic transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8p1i, PDBe:8p1i, PDBj:8p1i
PDBsum8p1i
PubMed38177534
UniProtA0A332Z023

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