Structure of PDB 8p0i Chain A

Receptor sequence
>8p0iA (length=857) Species: 9606 (Homo sapiens) [Search protein sequence]
LFPWAQIRLPTAVVPLRYELSLHPNLTSMTFRGSVTISVQALQVTWNIIL
HSTGHNISRVTFMSAVSSQEKQAEILEYAYHGQIAIVAPEALLAGHNYTL
KIEYSANISSSYYGFYGFSYTDESNEKKYFAATQFEPLAARSAFPCFDEP
AFKATFIIKIIRDEQYTALSNMPKKSSVVLDDGLVQDEFSESVKMSTYLV
AFIVGEMKNLSQDVNGTLVSIYAVPEKIGQVHYALETTVKLLEFFQNYFE
IQYPLKKLDLVAIPDFEAGAMENWGLLTFREETLLYDSNTSSMADRKLVT
KIIAHELAHQWFGNLVTMKWWNDLWLNEGFATFMEYFSLEKIFKELSSYE
DFLDARFKTMKKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKGSSLLLML
KTYLSEDVFQHAVVLYLHNHSYASIQSDDLWDSFNEVTNQTLDVKRMMKT
WTLQKGFPLVTVQKKGKELFIQQERFFLNTSYLWHIPLSYVTEGRNYSKY
QSVSLLDKKSGVINLTEEVLWVKVNINMNGYYIVHYADDDWEALIHQLKI
NPYVLSDKDRANLINNIFELAGLGKVPLKRAFDLINYLGNENHTAPITEA
LFQTDLIYNLLEKLGYMDLASRLVTRVFKLLQNQIQQQTWTDEGTPSMRE
LRSALLEFACTHNLGNCSTTAMKLFDDWMASNGTQSLPTDVMTTVFKVGA
KTDKGWSFLLGKYISIGSEAEKNKILEALASSEDVRKLYWLMKSSLNGDN
FRTQKLSFIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLGSYTIQNIVA
GSTYLFSTKTHLSEVQAFFENQSEATFRLRCVQEALEVIQLNIQWMEKNL
KSLTWWL
3D structure
PDB8p0i Stabilization of the open conformation omicron f insulin-regulated aminopeptidase by a novel substrate-selective small-molecule inhibitor.
ChainA
Resolution3.5 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WC3 A Y272 E295 P296 A429 E431 H464 E465 H468 E487 E541 F544 Y113 E136 P137 A270 E272 H305 E306 H309 E328 E382 F385
BS02 ZN A H464 H468 E487 H305 H309 E328
External links
PDB RCSB:8p0i, PDBe:8p0i, PDBj:8p0i
PDBsum8p0i
PubMed39167040
UniProtQ9UIQ6|LCAP_HUMAN Leucyl-cystinyl aminopeptidase (Gene Name=LNPEP)

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