Structure of PDB 8oz5 Chain A

Receptor sequence

>8oz5A (length=514) Species: 96773 (Thauera chlorobenzoica)

ERVGEKDLRAALEWFRSKGYLVETNKEVNPDLEITGLQKIFDGSLPMLFN
NVKDMPHARAITNLFGDIRVVEELFGWENSLDRVKKVARAIDHPLKPVII
GQDEAPVQEEVLTTDLDVNKWLTAIRHTPLETEMTIGSGISCVVGPYFDG
GSHIGYNRMNFRWGNVGTFQISPGSHMWQVMTEHYKDDEPIPLTMCFGVP
PSCTYVAGAGFDYAILPKGCDEIGIAGAIQGSPVRLVKCRTIDAYTLADA
EYVLEGYLHPRDKRYETAESEAADIQGRFHFHPEWAGYMGKAYKAPTFHV
TAITMRRRESKPIIFPLGVHTADDANIDTSVRESAIFALCERLQPGIVQN
VHIPYCMTDWGGCIIQVKKRNQIEEGWQRNFLAAILACSQGMRLAIAVSE
DVDIYSMDDIMWCLTTRVNPQTDILNPLPGGRGQTFMPAERMTSGDKQWT
ASNTQFEGGMGIDATVPYGYESDFHRPVYGVDLVKPENFFDAKDIDKMKS
RMAGWVLSLARTGR

3D structure

• PDB: 8oz5 Cryo-EM structure of Phthaloyl-CoA decarboxylase (Pcd) bound with substrate analog/inhibitor, 2-CN-benzoyl-CoA
• Chain: A
• Resolution: 2.04 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	BYN	A	G150 H166 Y169 R171 Q183 S185 S188 H189 A220 A222 G223 Y226 E235 L330 D337	G137 H153 Y156 R158 Q170 S172 S175 H176 A207 A209 G210 Y213 E222 L317 D324
BS02	WC8	A	Q183 S185 P186 T195 Y198 Q289 E297 W298 Y306 W373 F449 T463	Q170 S172 P173 T182 Y185 Q276 E284 W285 Y293 W360 F436 T450
BS03	FE	A	H166 H189 E235	H153 H176 E222
BS04	FE	A	R430 D436 D476 A477 T478	R417 D423 D463 A464 T465
BS05	CA	A	T342 E346 I366	T329 E333 I353

Gene Ontology

Molecular Function

• GO:0016831 carboxy-lyase activity

Biological Process

• GO:0033494 ferulate metabolic process
• GO:0046281 cinnamic acid catabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:8oz5, PDBe:8oz5, PDBj:8oz5
• PDBsum: 8oz5
• UniProt: A0A193DUB4