Structure of PDB 8oy8 Chain A

Receptor sequence

>8oy8A (length=460) Species: 192952 (Methanosarcina mazei Go1) [Search protein sequence]

IMNPKRIRALKSGKQGDGPVVYWMSRDQRAEDNWALLFSRAIAKEANVPV
VVVFCLTDEFLEAGIRQYEFMLKGLQELEVSLSRKKIPSFFLRGDPGEKI
SRFVKDYNAGTLVTDFSPLRIKNQWIEKVISGISIPFFEVDAHNVVPCWE
ASQKHEYAAHTFRPKLYALLPEFLEEFPELEPNSVTPVETLSDVLETGVK
ALLPERALLKNKDPLFEPWHFEPGEKAAKKVMESFIADRLDSYGALRNDP
TKNMLSNLSPYLHFGQISSQRVVLEVEKAESNPGSKKAFLDEILIWKEIS
DNFCYYNPGYDGFESFPSWAKESLNAHRNDVRSHIYTLEEFEAGKTHDPL
WNASQMELLSTGKMHGYMRMYWAKKILEWSESPEKALEIAICLNDRYELD
GRDPNGYAGIAWSIGGVHDRAWGEREVTGKIRYMSYEGCKRKFDVKLYIE
KYSALDKLAA

3D structure

PDB

8oy8 Time-resolved crystallography captures light-driven DNA repair

Chain

Resolution

2.39 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

4.1.99.3: deoxyribodipyrimidine photo-lyase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	A160 H161 E301 W305 M379 W421 W431 R441 Y442 M443 S444 R450 K451	A159 H160 E292 W296 M370 W412 W422 R432 Y433 M434 S435 R441 K442
BS02	dna	A	Y158 W328 R429 A430 W431 G432 E433 K439 R450	Y157 W319 R420 A421 W422 G423 E424 K430 R441
BS03	FDA	A	Y252 L264 S265 N266 S268 L271 E301 W305 K372 R378 M379 N403 D409 N414 G415	Y243 L255 S256 N257 S259 L262 E292 W296 K363 R369 M370 N394 D400 N405 G406

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0003677	DNA binding
GO:0003904	deoxyribodipyrimidine photo-lyase activity
GO:0016829	lyase activity

	Biological Process
GO:0000719	photoreactive repair
GO:0006281	DNA repair

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:8oy8, PDBe:8oy8, PDBj:8oy8
PDBsum	8oy8
PubMed	38033070
UniProt	Q8PYK9

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