Structure of PDB 8oy4 Chain A

Receptor sequence

>8oy4A (length=452) Species: 192952 (Methanosarcina mazei Go1) [Search protein sequence]

MNPKRIRALKSGKQGDGPVVYWMSRDQRAEDNWALLFSRAIAKEANVPVV
VVFCLTDEFLEAGIRQYEFMLKGLQELEVSLSRKKIPSFFLRGDPGEKIS
RFVKDYNAGTLVTDFSPLRIKNQWIEKVISGISIPFFEVDAHNVVPCWEA
SQKHEYAAHTFRPKLYALLPEFLEEFPELEPNSVTTLSDVLETGVKALLP
ERALLKNKDPLFEPWHFEPGEKAAKKVMESFIADRLDSYGALRNDPTKNM
LSNLSPYLHFGQISSQRVVLEVEKAESNPGSKKAFLDEILIWKEISDNFC
YYNPGYDGFESFPSWAKESLNAHRNDVRSHIYTLEEFEAGKTHDPLWNAS
QMELLSTGKMHGYMRMYWAKKILEWSESPEKALEIAICLNDRYELDGRDP
NGYAGIAWSIGGVHDRAWGEREVTGKIRYMSYEGCKRKFDVKLYIEKYSA
LD

3D structure

PDB

8oy4 Time-resolved crystallography captures light-driven DNA repair

Chain

Resolution

2.35 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

4.1.99.3: deoxyribodipyrimidine photo-lyase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	H161 R164 R256 E301 W305 Y376 M379 W421 W431 R441 Y442 M443 S444 R450 K451	H159 R162 R243 E288 W292 Y363 M366 W408 W418 R428 Y429 M430 S431 R437 K438
BS02	dna	A	Y158 R429 W431 G432 E433 K439 R450	Y156 R416 W418 G419 E420 K426 R437
BS03	FDA	A	Y252 S265 N266 S268 F298 E301 I302 W305 K306 K372 R378 N403 D409 N414 G415	Y239 S252 N253 S255 F285 E288 I289 W292 K293 K359 R365 N390 D396 N401 G402

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0003677	DNA binding
GO:0003904	deoxyribodipyrimidine photo-lyase activity
GO:0016829	lyase activity

	Biological Process
GO:0000719	photoreactive repair
GO:0006281	DNA repair

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:8oy4, PDBe:8oy4, PDBj:8oy4
PDBsum	8oy4
PubMed	38033070
UniProt	Q8PYK9

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