Structure of PDB 8oxx Chain A

Receptor sequence
>8oxxA (length=460) Species: 9606 (Homo sapiens) [Search protein sequence]
AALGVQSINWQTAFNRQAHHTDKFSSQELILRRGQNFQVLMIMNKGLGSN
ERLEFIVSTGPYPSESAMTKAVFPLSNGSSGGWSAVLQASNGNTLTISIS
SPASAPIGRYTMALQIFSQGGISSVKLGTFILLFNPWLNVDSVFMGNHAE
REEYVQEDAGIIFVGSTNRIGMIGWNFGQFEEDILSICLSILDRSLNFRR
DAATDVASRNDPKYVGRVLSAMINSNDDNGVLAGNWSGTYTGGRDPRSWN
GSVEILKNWKKSGFSPVRYGQCWVFAGTLNTALRSLGIPSRVITNFNSAH
DTDRNLSVDVYYDPMGNPLDKGSDSVWNFHVWNEGWFVRSDLGPSYGGWQ
VLDATPQERSQGVFQCGPASVIGVREGDVQLNFDMPFIFAEVNADRITWL
YDNTTGKQWKNSVNSHTIGRYISTKAVGSNARMDVTDKYKYPEGSDQERQ
VFQKALGKLK
3D structure
PDB8oxx Autoantibody binding and unique enzyme-substrate intermediate conformation of human transglutaminase 3.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.13: protein-glutamine gamma-glutamyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A A222 N225 N227 D229 A221 N224 N226 D228
BS02 CA A N394 S416 E444 E449 N393 S415 E443 E448
BS03 CA A D302 D304 N306 S308 D310 D325 D301 D303 N305 S307 D309 D324
BS04 P6S A W274 F330 W273 F329
BS05 ONL A W237 Q272 C273 W328 F330 H331 W236 Q271 C272 W327 F329 H330
BS06 DVA A W328 N329 W327 N328
Gene Ontology
Biological Process
GO:0018149 peptide cross-linking

View graph for
Biological Process
External links
PDB RCSB:8oxx, PDBe:8oxx, PDBj:8oxx
PDBsum8oxx
PubMed37798283
UniProtQ08188|TGM3_HUMAN Protein-glutamine gamma-glutamyltransferase E (Gene Name=TGM3)

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