Structure of PDB 8oxc Chain A

Receptor sequence
>8oxcA (length=1035) Species: 9606 (Homo sapiens) [Search protein sequence]
TWQVKANDRKYHEQSKYANNAIKTYKYNAFTFIPMNLFEQFKRAANLYFL
ALLILQAVPQISTLAWYTTLVPLLVVLGVTAIKDLVDDVARHKMDKEINN
RTCEVIKDGRFKVAKWKEIQVGDVIRLKKNDFVPADILLLSSSEPNSLCY
VETAELDGETNLKFKMSLEITDQYLQREDTLATFDGFIECEEPNNRLDKF
TGTLFWRNTSFPLDADKILLRGCVIRNTDFCHGLVIFAGADTKIMKNSGK
TRFKRTKIDYLMNYMVYTIFVVLILLSAGLAIGHAYWEAQVGNSSWYLYD
GEDDTPSYRGFLIFWGYIIVLNTMVPISLYVSVEVIRLGQSHFINWDLQM
YYAEKDTPAKARTTTLNEQLGQIHYIFSDKTGTLTQNIMTFKKCCINGQI
YGDHRDVDFSWNTYADGKLAFYDHYLIEQIQSGKEPEVRQFFFLLAVCHT
VMVDRTDGQLNYQAASPDEGALVNAARNFGFAFLARTQNTITISELGTER
TYNVLAILDFNSDRKRMSIIVRTPEGNIKLYCKGADTVIYERLHRMNPTK
QETQDALDIFANETLRTLCLCYKEIEEKEFTEWNKKFMAASVASTNRDEA
LDKVYEEIEKDLILLGATAIEDKLQDGVPETISKLAKADIKIWVLTGDKK
ETAENIGFACELLTEDTTICYGEDINSLLHARMENFFPPGGNRALIITGS
WLNEILLEKRRLEAKKEQRQKNFVDLACECSAVICCRVTPKQKAMVVDLV
KRYKKAITLAIGDGANDVNMIKTAHIGVGISGQEGMQAVMSSDYSFAQFR
YLQRLLLVHGRWSYIRMCKFLRYFFYKNFAFTLVHFWYSFFNGYSAQTAY
EDWFITLYNVLYTSLPVLLMGLLDQDVSDKLSLRFPGLYIVGQRDLLFNY
KRFFVSLLHGVLTSMILFFIPLGAYLQTVGQDGEAPSDYQSFAVTIASAL
VITVNFQIGLDTSYWTFVNAFSIFGSIALYFGIMFDFTASNALRQPYIWL
TIILTVAVCLLPVVAIRFLSMTIWPSESDKIQKHR
3D structure
PDB8oxc Activation and substrate specificity of the human P4-ATPase ATP8B1.
ChainA
Resolution2.58 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 7.6.2.1: P-type phospholipid transporter.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VN4 A G233 D454 K455 T456 T732 G733 K873 N896 G158 D379 K380 T381 T646 G647 K743 N766
BS02 MG A D454 T456 D893 D379 T381 D763
BS03 PIE A Q131 T143 T144 P147 N397 I402 S403 N989 V990 S994 L995 L998 F1101 G1105 Q56 T68 T69 P72 N322 I327 S328 N859 V860 S864 L865 L868 F971 G975
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0005215 transporter activity
GO:0005319 lipid transporter activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0015247 aminophospholipid flippase activity
GO:0016887 ATP hydrolysis activity
GO:0046872 metal ion binding
GO:0090554 phosphatidylcholine floppase activity
GO:0090556 phosphatidylserine floppase activity
GO:0140326 ATPase-coupled intramembrane lipid transporter activity
GO:0140345 phosphatidylcholine flippase activity
GO:0140346 phosphatidylserine flippase activity
GO:1901612 cardiolipin binding
Biological Process
GO:0006855 xenobiotic transmembrane transport
GO:0006869 lipid transport
GO:0007030 Golgi organization
GO:0007605 sensory perception of sound
GO:0008206 bile acid metabolic process
GO:0015711 organic anion transport
GO:0015721 bile acid and bile salt transport
GO:0015914 phospholipid transport
GO:0015917 aminophospholipid transport
GO:0021650 vestibulocochlear nerve formation
GO:0032534 regulation of microvillus assembly
GO:0034220 monoatomic ion transmembrane transport
GO:0045176 apical protein localization
GO:0045332 phospholipid translocation
GO:0045892 negative regulation of DNA-templated transcription
GO:0060119 inner ear receptor cell development
GO:0140331 aminophospholipid translocation
GO:1903729 regulation of plasma membrane organization
GO:2001225 regulation of chloride transport
Cellular Component
GO:0005654 nucleoplasm
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0012505 endomembrane system
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0016604 nuclear body
GO:0032420 stereocilium
GO:0042995 cell projection
GO:1990531 phospholipid-translocating ATPase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8oxc, PDBe:8oxc, PDBj:8oxc
PDBsum8oxc
PubMed37980352
UniProtO43520|AT8B1_HUMAN Phospholipid-transporting ATPase IC (Gene Name=ATP8B1)

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