Structure of PDB 8ox4 Chain A

Receptor sequence
>8ox4A (length=870) Species: 9606 (Homo sapiens) [Search protein sequence]
TFIPMNLFEQFKRAANLYFLALLILQAVPQISTLAWYTTLVPLLVVLGVT
AIKDLVDDVARHKMDKEINFKRTKIDYLMNYMVYTIFVVLILLSAGLAIG
HAYWEAQVGNSSWYLYDGEDDTPSYRGFLIFWGYIIVLNTMVPISLYVSV
EVIRLGQSHFINWDLQMYYAEKDTPAKARTTTLNEQLGQIHYIFSDKTGT
LTQNIMTFKKCCINGQIYGDHRDVDFSWNTYADGKLAFYDHYLIEQIQSG
KEPEVRQFFFLLAVCHTVMVDRTDGQLNYQAASPDEGALVNAARNFGFAF
LARTQNTITISELGTERTYNVLAILDFNSDRKRMSIIVRTPEGNIKLYCK
GADTVIYERLHRMNPTKQETQDALDIFANETLRTLCLCYKEIEEKEFTEW
NKKFMAASVASTNRDEALDKVYEEIEKDLILLGATAIEDKLQDGVPETIS
KLAKADIKIWVLTGDKKETAENIGFACELLTEDTTICYGEDINSLLHARM
ENQRGNRALIITGSWLNEILLETQSKRRLEAKKEQRQKNFVDLACECSAV
ICCRVTPKQKAMVVDLVKRYKKAITLAIGDGANDVNMIKTAHIGVGISGQ
EGMQAVMSSDYSFAQFRYLQRLLLVHGRWSYIRMCKFLRYFFYKNFAFTL
VHFWYSFFNGYSAQTAYEDWFITLYNVLYTSLPVLLMGLLDQDVSDKLSL
RFPGLYIVGQRDLLFNYKRFFVSLLHGVLTSMILFFIPLGAYLQTVGQDG
EAPSDYQSFAVTIASALVITVNFQIGLDTSYWTFVNAFSIFGSIALYFGI
MFDFHSAGIHVLFPSAFQFTGTASNALRQPYIWLTIILTVAVCLLPVVAI
RFLSMTIWPSESDKIQKHRK
3D structure
PDB8ox4 Activation and substrate specificity of the human P4-ATPase ATP8B1.
ChainA
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 7.6.2.1: P-type phospholipid transporter.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ACP A D454 T456 E555 F596 S598 G620 R652 L654 T732 G733 D734 R867 D196 T198 E286 F327 S329 G351 R383 L385 T463 G464 D465 R554
BS02 MG A D454 T456 D893 E914 D196 T198 D580 E601
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0005215 transporter activity
GO:0005319 lipid transporter activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0015247 aminophospholipid flippase activity
GO:0016887 ATP hydrolysis activity
GO:0046872 metal ion binding
GO:0090554 phosphatidylcholine floppase activity
GO:0090556 phosphatidylserine floppase activity
GO:0140326 ATPase-coupled intramembrane lipid transporter activity
GO:0140345 phosphatidylcholine flippase activity
GO:0140346 phosphatidylserine flippase activity
GO:1901612 cardiolipin binding
Biological Process
GO:0006855 xenobiotic transmembrane transport
GO:0006869 lipid transport
GO:0007030 Golgi organization
GO:0007605 sensory perception of sound
GO:0008206 bile acid metabolic process
GO:0015711 organic anion transport
GO:0015721 bile acid and bile salt transport
GO:0015914 phospholipid transport
GO:0015917 aminophospholipid transport
GO:0021650 vestibulocochlear nerve formation
GO:0032534 regulation of microvillus assembly
GO:0034220 monoatomic ion transmembrane transport
GO:0045176 apical protein localization
GO:0045332 phospholipid translocation
GO:0045892 negative regulation of DNA-templated transcription
GO:0060119 inner ear receptor cell development
GO:0140331 aminophospholipid translocation
GO:1903729 regulation of plasma membrane organization
GO:2001225 regulation of chloride transport
Cellular Component
GO:0005654 nucleoplasm
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0012505 endomembrane system
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0016604 nuclear body
GO:0032420 stereocilium
GO:0042995 cell projection
GO:1990531 phospholipid-translocating ATPase complex

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8ox4, PDBe:8ox4, PDBj:8ox4
PDBsum8ox4
PubMed37980352
UniProtO43520|AT8B1_HUMAN Phospholipid-transporting ATPase IC (Gene Name=ATP8B1)

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