Structure of PDB 8owx Chain A

Receptor sequence
>8owxA (length=233) Species: 9606 (Homo sapiens) [Search protein sequence]
VSDFKQQKLEQEAQKNWDLFYKRNSTNHWTTREFEELRSCREFEDQKLTM
LEAGCGVGNCLFPLLEEDPNIFAYACDFSPRAIEYVKQNPLYDTERCKVF
QCDLTKDDLLDHVPPESVDVVMLIFVLSAVHPDKMHLVLQNIYKVLKPGK
SVLFRDYGLYDHAMLRFKASSKLGENFYVRQDGTRSYFFTDDFLAQLFMD
TGYEEVVNEYVFRETVLCVPRVFLQSKFLKPPK
3D structure
PDB8owx Structural basis of the cooperation between the m3C RNA-methyltransferase METTL6 with SerRS amino-acyl-synthetase for tRNA recognition
ChainA
Resolution2.601 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A W45 Y49 W62 E85 G87 G89 D110 F111 C135 D136 L137 I157 F158 V159 V163 W17 Y21 W29 E52 G54 G56 D77 F78 C102 D103 L104 I124 F125 V126 V130
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0008173 RNA methyltransferase activity
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
GO:0019899 enzyme binding
GO:0052735 tRNA (cytidine-3-)-methyltransferase activity
Biological Process
GO:0006400 tRNA modification
GO:0008033 tRNA processing
GO:0030488 tRNA methylation
GO:0032259 methylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:8owx, PDBe:8owx, PDBj:8owx
PDBsum8owx
PubMed38918637
UniProtQ8TCB7|METL6_HUMAN tRNA N(3)-methylcytidine methyltransferase METTL6 (Gene Name=METTL6)

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